This article explores the strategies employed by Russian multinational corporations (MNCs) in response to Western economic sanctions. It delves into the nature of these sanctions, their extensive impact on Russia’s economy and corporate operations, and the innovative strategies that Russian MNCs have utilised to adapt and thrive within a restrictive global environment. These strategies include market diversification, leveraging non-Western alliances, investing in domestic innovation, and developing alternative financial mechanisms. The research draws on case studies and sector-specific analyses to illustrate the resilience of Russian corporations under pressure and their ability to navigate complex international challenges. By presenting these findings, the study highlights how Western sanctions have catalysed significant adaptations within Russian industries, fostering a deeper reliance on domestic capabilities and strengthening non-Western partnerships. Furthermore, the article examines the ripple effects of these measures on global supply chains, geopolitical alliances, and international regulatory practices. Additionally, the insights gained are relevant for policymakers, academics, and business leaders aiming to understand the dynamic interplay between sanctions and corporate strategy, offering valuable lessons for navigating economic challenges and fostering long-term resilience in an interconnected global economy. This analysis underscores the broader implications of Western economic measures on global trade, innovation, and international business resilience.